Reaction: MDP elicits a NOD2 response
- in pathway: NOD1/2 Signaling Pathway
Muramyl dipeptide (MDP) is an essential structural component of bacterial peptidoglycan (PGN) and the minimal elicitor recognized by NOD2. As MDP is present in nearly all bacteria NOD2 is a general sensor of bacteria. NOD2 has additionally been reported to respond to ssRNA (Sabbah et al. 2009) and play a role in T cell activation (Shaw et al. 2011).
Reaction - small molecule participants:
MDP [cytosol]
Reactome.org reaction link: R-HSA-168412
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Reaction input - small molecules:
muramyl dipeptide
Reaction output - small molecules:
Reactome.org link: R-HSA-168412