Reaction: UDP-glucose is oxidised to UDP-glucuronate
- in pathway: Formation of the active cofactor, UDP-glucuronate
UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of UDP-glucose to UDP-glucuronic acid. The cytosolic enzyme is active as a hexamer and performs two successive oxidations to convert the 6'-hydroxyl of UDP-glucose to a carboxylate with concurrent reduction of 2 mol of NAD+ to NADH.
Reaction - small molecule participants:
H+ [cytosol]
UDP-GlcA [cytosol]
NADH [cytosol]
H2O [cytosol]
UDP-D-glucose(2-) [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-173597
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Reaction input - small molecules:
water
UDP-D-glucose(2-)
NAD(1-)
Reaction output - small molecules:
hydron
UDP-alpha-D-glucuronate(3-)
NADH(2-)
Reactome.org link: R-HSA-173597