Reaction: Phosphorylation of Cyclin A:Cdk2 at Tyr 15
- in pathway: Cyclin A:Cdk2-associated events at S phase entry
The CDK activity of the Cyclin A:Cdk2 complex is inhibited by phosphorylation at Tyr-15 by the WEE1 kinase (Gu et al. 1992, Wu et al. 2001). WEE1-mediated phosphorylation of cyclin A-bound CDK2 is positively regulated by CABLES1 (Wu et al. 2001).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-174164
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-174164