Reaction: GCL ligates L-Glu to L-Cys
- in pathway: Glutathione synthesis and recycling
The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).
Reaction - small molecule participants:
Pi [cytosol]
gGluCys [cytosol]
ADP [cytosol]
L-Glu [cytosol]
L-Cys [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-174367
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Reaction input - small molecules:
L-glutamate(1-)
L-cysteine zwitterion
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
L-gamma-glutamyl-L-cysteinate(1-)
ADP(3-)
Reactome.org link: R-HSA-174367