Reaction: SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen
- in pathway: Transport of nucleotide sugars
The UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (SLC35D1) in hexameric form transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytosol into the ER lumen across the ER membrane (Muraoka et al. 2001). These substrates participate in glucuronidation and/or chondroitin sulfate biosynthesis.
Reaction - small molecule participants:
UDP-GlcNAc [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
UDP-GlcA [cytosol]
UDP-GlcNAc [cytosol]
UDP-GlcNAc [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
UDP-GlcA [cytosol]
UDP-GlcNAc [cytosol]
Reactome.org reaction link: R-HSA-174368
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
UDP-alpha-D-glucuronate(3-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
Reaction output - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
UDP-alpha-D-glucuronate(3-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
UDP-alpha-D-glucuronate(3-)
Reactome.org link: R-HSA-174368