Reaction: MTR transfers CH3 from MeCbl to HCYS
- in pathway: Sulfur amino acid metabolism
Methionine synthase (MTR) mediates the continuous shuttling of cobalamin (Cbl) between two forms, cob(I)alamin and MeCbl. In this half reaction, the methyl group from MeCbl is transferred to homocysteine (HYCS) to form methionine and regenerate cob(I)alamin (Hall et al. 2000; Leclerc et al. 1996).
Reaction - small molecule participants:
L-Met [cytosol]
HCYS [cytosol]
L-Met [cytosol]
HCYS [cytosol]
L-Met [cytosol]
HCYS [cytosol]
Reactome.org reaction link: R-HSA-174374
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Reaction input - small molecules:
homocysteine zwitterion
homocysteine zwitterion
homocysteine zwitterion
Reaction output - small molecules:
L-methionine zwitterion
L-methionine zwitterion
L-methionine zwitterion
Reactome.org link: R-HSA-174374