Reaction: The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere
- in pathway: Telomere C-strand synthesis initiation
The complementary C-strand at telomeres is synthesized by the DNA polymerase alpha:primase complex (Nakamura et al. 2005) using conventional RNA priming (Wang et al. 1984). Interaction of the DNA polymerase alpha complex with the G-strand-bound CST complex is needed for successful priming of the C-strand (Feng et al. 2018).
Reaction - small molecule participants:
NTP [nucleoplasm]
Reactome.org reaction link: R-HSA-174425
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Reaction input - small molecules:
nucleoside 5'-triphoshate(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-174425