Reaction: UGTs transfer GlcA from UDP-GlcA to O-centre substrates
- in pathway: Glucuronidation
Typical O-centred substrates were chosen as examples for these isozymes. Many UDP-glucuronosyltransferases (UGTs) can transfer the glucuronyl moiety (GlcA) from UDP-GlcA to the O-centre functional group of many substrates, including salicylate (ST), to form 4-O-glucuronides (Casarett & Doull 1995, Babu et al. 1996; Kuehl et al, 2006).
Reaction - small molecule participants:
UDP [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
UDP [endoplasmic reticulum lumen]
UDP-GlcA [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-174931
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
UDP
UDP
Reactome.org link: R-HSA-174931