Reaction: 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP
- in pathway: Cytosolic sulfonation of small molecules
Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).
Reaction - small molecule participants:
3,3'-diiodothyronine 4-sulfate [cytosol]
PAP [cytosol]
PAPS [cytosol]
3,3'-diiodothyronine [cytosol]
Reactome.org reaction link: R-HSA-176474
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Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
3,3'-diiodothyronine
Reaction output - small molecules:
3,3'-diiodo-L-thyronine sulfate
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-176474