Reaction: Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
- in pathway: Cytosolic sulfonation of small molecules
PAP is generated as a byproduct of sulfonation reactions in vivo; its hydrolysis to AMP and orthophosphate returns its constituents to the pool of molecules available for cytosolic nucleotide metabolism. Bisphosphate 3'-nucleotidase 1catalyzes this reaction efficiently in vitro; whether other nucleotidases also play a role in PAP breakdown in vivo is unknown.
Reaction - small molecule participants:
Pi [cytosol]
AMP [cytosol]
H2O [cytosol]
PAP [cytosol]
Reactome.org reaction link: R-HSA-176606
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Reaction input - small molecules:
water
adenosine 3',5'-bismonophosphate(4-)
Reaction output - small molecules:
hydrogenphosphate
adenosine 5'-monophosphate(2-)
Reactome.org link: R-HSA-176606