Reaction: cholesterol + PAPS => cholesterol sulfate + PAP
- in pathway: Cytosolic sulfonation of small molecules
The 3-hydroxyl groups of a number of sterols can undergo sulfonation. Cholesterol sulfate is particularly abundant in the body, and may have both regulatory and biosynthetic functions (Strott and Higashi 2003). Its synthesis is catalyzed by the b isoform of SULT2B1 (Fuda et al. 2002; Javitt et al. 2001).
Reaction - small molecule participants:
cholesterol sulfate [cytosol]
PAP [cytosol]
CHOL [cytosol]
PAPS [cytosol]
Reactome.org reaction link: R-HSA-176609
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Reaction input - small molecules:
cholesterol
3'-phosphonato-5'-adenylyl sulfate(4-)
Reaction output - small molecules:
cholesterol sulfate(1-)
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-176609