Reaction: N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
- in pathway: Cytosolic sulfonation of small molecules
Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluorene converts it to a potent carcinogen. SULT1A2 (Glatt 2000) and SULT1C1 and 1C2 (Sakakibara et al. 1998) catalyze this reaction.
Reaction - small molecule participants:
AAF-N-S [cytosol]
PAP [cytosol]
PAPS [cytosol]
N-hydroxy-2-acetylaminofluorene [cytosol]
Reactome.org reaction link: R-HSA-176669
======
Reaction input - small molecules:
3'-phosphonato-5'-adenylyl sulfate(4-)
N-hydroxy-2-acetamidofluorene
Reaction output - small molecules:
2-acetamidofluorene N-sulfate
adenosine 3',5'-bismonophosphate(4-)
Reactome.org link: R-HSA-176669