Reaction: phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A
- in pathway: Conjugation of phenylacetate with glutamine
Phenylacetyl CoA and glutamine react to form phenylacetyl glutamine and Coenzyme A. The enzyme that catalyzes this reaction has been purified from human liver mitochondria and shown to be a distinct polypeptide species from glycine-N-acyltransferase (Webster et al. 1976). This human glutamine-N-acyltransferase activity has not been characterized by sequence analysis at the protein or DNA level, however, and thus cannot be associated with a known human protein in the annotation of phenylacetate conjugation.
Reaction - small molecule participants:
CoA-SH [mitochondrial matrix]
phenylacetyl glutamine [mitochondrial matrix]
L-Gln [mitochondrial matrix]
phenylacetyl-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-177160
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Reaction input - small molecules:
L-glutamine zwitterion
phenylacetyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
N(2)-phenylacetyl-L-glutaminate
Reactome.org link: R-HSA-177160