Reaction: DS is cleaved from its proteoglycan
- in pathway: CS/DS degradation
Dermatan sulfate (DS) is thought to be hydrolysed from its dermatan sulfate proteoglycan (DSPG) by an unknown human beta-xylosidase. The reaction shown here is based on studies of a rabbit lysosomal enzyme fraction assay (Takagaki et al. 1988). DSPG can have many DS chains attached to it; this example shows the hydrolysis of one DS chain from DSPG.
Reaction - small molecule participants:
ChEBI:63519 chain [lysosomal lumen]
H2O [lysosomal lumen]
Reactome.org reaction link: R-HSA-1793176
======
Reaction input - small molecules:
water
Reaction output - small molecules:
beta-D-GalNAc4S-(1->4)-beta-D-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
Reactome.org link: R-HSA-1793176