Reaction: HYAL1 hydrolyses Chondroitin chains
- in pathway: CS/DS degradation
Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in chondroitin (or dermatan). It also hydrolyses this linkage in hyaluronate, another glycosaminoglycan (GAG) composed of repeating disaccharide units but the only one which is non-sulfated (Frost et al. 1997). There are five human hyaluronidases (HYALs, endo-beta-acetyl-hexosaminidases), HYAL1-4, and PH-20 (Jedrzejas & Stern 2005).
Reaction - small molecule participants:
CS/HS precursor [lysosomal lumen]
H2O [lysosomal lumen]
Reactome.org reaction link: R-HSA-1793209
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Reaction input - small molecules:
water
Reaction output - small molecules:
beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
Reactome.org link: R-HSA-1793209