Reaction: Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
- in pathway: Keratan sulfate degradation
Keratan sulfate (KS) is cleaved from its KS proteoglycan (KSPG) by an as yet unknown beta-galactosidase. It performs a similar function to beta-galactosidase GLB1 (Asp et al. 1969). A simplified version of KS is used to demonstrate cleavage reactions.
Reaction - small molecule participants:
Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen]
H2O [lysosomal lumen]
Reactome.org reaction link: R-HSA-1793217
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Reaction input - small molecules:
water
Reaction output - small molecules:
beta-D-Galp6S-(1->4)-beta-D-GlcpNAc6S-(1->3)-beta-D-Galp-(1->4)-beta-D-GlcpNAc6S-(1->3)-D-Galp
Reactome.org link: R-HSA-1793217