Reaction: GAB1 binds phosphatidylinositol-3,4,5-trisphosphate
- in pathway: GAB1 signalosome
The pleckstrin homology (PH) domain of GAB1 binds to PIP3 and can target GAB1 to the plasma membrane in response to EGF stimulation. This mechanism provides a positive feedback loop with respect to PI3K activation, to enhance EGFR signalling.
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
Reactome.org reaction link: R-HSA-179467
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reaction output - small molecules:
Reactome.org link: R-HSA-179467