Reaction: Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand
- in pathway: APOBEC3G mediated resistance to HIV-1 infection
During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3' end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5' to 3' regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)
The polypurine tract is essential for plus strand synthesis and is located at the 3' end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5' to 3' regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)
Reaction - small molecule participants:
NH3 [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-180632
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Reaction input - small molecules:
water
Reaction output - small molecules:
ammonia
Reactome.org link: R-HSA-180632