Reaction: I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol
- in pathway: Synthesis of IP2, IP, and Ins in the cytosol
Inositol monophosphatase 1 (IMPA1) and 2 (IMPA2) homodimers dephosphorylate inositol 1-phosphate (I1P) to inositol (Ins). In vitro, IMPA1 and 2 differ in their pH optima and IMPA1 has a significantly greater activity on IP4 than does IMPA2 (McAllister et al. 1992, Ohnishi et al. 2007).
Reaction - small molecule participants:
Pi [cytosol]
Ins [cytosol]
H2O [cytosol]
I1P [cytosol]
Reactome.org reaction link: R-HSA-1855154
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Reaction input - small molecules:
water
1D-myo-inositol 1-phosphate
Reaction output - small molecules:
hydrogenphosphate
myo-inositol
Reactome.org link: R-HSA-1855154