Reaction: 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5) to make inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Saiardi et al. 2001, Mulugu et al. 2007).
Reaction - small molecule participants:
ADP [nucleoplasm]
1,5-(PP)2-IP4 [nucleoplasm]
ATP [nucleoplasm]
1-PP-IP5 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855157
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Reaction input - small molecules:
ATP(4-)
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)
Reaction output - small molecules:
ADP(3-)
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)
Reactome.org link: R-HSA-1855157