Reaction: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 5-triphospho- 1,2,3,4,6-pentakisphosphate (5-PPP-IP5).
The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K3 (Saiardi et al. 2001, Draskovic et al. 2008).
The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K3 (Saiardi et al. 2001, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [cytosol]
5-PPP-IP5 [cytosol]
5-PP-IP5 [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1855158
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Reaction input - small molecules:
5-diphospho-1D-myo-inositol pentakisphosphate(13-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
Reactome.org link: R-HSA-1855158