Reaction: PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Diphosphoinositol polyphosphate phosphohydrolase 2, also known as nucleoside diphosphate-linked moiety X motif 4 (NUDT4), dephosphorylates diphospho- tetrakisphosphate (PP-IP4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5). The products made are: inositol 5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4); inositol 1-diphospho-3,4,5,6-tetrakisphosphate (1-PP-IP4); and inositol 3-diphospho-1,4,5,6-tetrakisphosphate (3-PP-IP4).
The following lists the above protein with its corresponding literature references: NUDT4 (Saiardi et al. 2001, Saiardi et al. 2000).
The following lists the above protein with its corresponding literature references: NUDT4 (Saiardi et al. 2001, Saiardi et al. 2000).
Reaction - small molecule participants:
Pi [cytosol]
I(1,3,4,5,6)P5 [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-1855166
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reactome.org link: R-HSA-1855166