Reaction: I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
- in pathway: Synthesis of IP3 and IP4 in the cytosol
The broad-specificity enzyme inositol-tetrakisphosphate 1-kinase (ITPK1) phosphorylates inositol 1,3,4-trisphosphate (I(1,3,4)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Wilson & Majerus 1996).
Reaction - small molecule participants:
ADP [cytosol]
I(1,3,4,5)P4 [cytosol]
ATP [cytosol]
I(1,3,4)P3 [cytosol]
Reactome.org reaction link: R-HSA-1855172
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Reaction input - small molecules:
ATP(4-)
1D-myo-inositol 1,3,4-trisphosphate(6-)
Reaction output - small molecules:
ADP(3-)
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
Reactome.org link: R-HSA-1855172