Reaction: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol-pentakisphosphate 2-kinase (IPPK - also known as IP5-2K) phosphorylates inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 1,2,3,4,5,6-hexakisphosphate (IP6) (Verbsky et al. 2002, Brehm et al. 2007, Choi et al. 2007).
Reaction - small molecule participants:
ADP [nucleoplasm]
IP6 [nucleoplasm]
ATP [nucleoplasm]
I(1,3,4,5,6)P5 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855176
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Reaction input - small molecules:
ATP(4-)
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reaction output - small molecules:
ADP(3-)
myo-inositol hexakisphosphate(12-)
Reactome.org link: R-HSA-1855176