Reaction: I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
- in pathway: Synthesis of IP2, IP, and Ins in the cytosol
Type I (INPP4A) and type II inositol-3,4-bisphosphate 4-phosphatase (INPP4B) dephosphorylate inositol 1,3,4-trisphosphate (I(1,3,4)P3) to inositol 1,3-bisphosphate (I(1,3)P2) (Norris et al. 1995, Norris et al. 1997).
Reaction - small molecule participants:
Pi [cytosol]
I(1,3)P2 [cytosol]
H2O [cytosol]
I(1,3,4)P3 [cytosol]
Reactome.org reaction link: R-HSA-1855180
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Reaction input - small molecules:
water
1D-myo-inositol 1,3,4-trisphosphate(6-)
Reaction output - small molecules:
hydrogenphosphate
myo-inositol 1,3-bisphosphate
Reactome.org link: R-HSA-1855180