Reaction: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 5-diphospho-(1,3,4,6)-tetrakisphosphate (5-PP-IP4) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
5-PP-IP4 [nucleoplasm]
ATP [nucleoplasm]
I(1,3,4,5,6)P5 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855181
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Reaction input - small molecules:
ATP(4-)
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reaction output - small molecules:
ADP(3-)
5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate
Reactome.org link: R-HSA-1855181