Reaction: 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1/2 (PPIP5K1) and 2 (PPIP5K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 1,5-bisdiphospho-2,3,4,6-tetrakisphosphate (1,5-(PP)2-IP4) (Fridy et al. 2007, Mulugu et al. 2007, Choi et al. 2007, Lin et al. 2009).
Reaction - small molecule participants:
1,5-(PP)2-IP4 [cytosol]
ADP [cytosol]
5-PP-IP5 [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-1855182
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Reaction input - small molecules:
5-diphospho-1D-myo-inositol pentakisphosphate(13-)
ATP(4-)
Reaction output - small molecules:
1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate(13-)
ADP(3-)
Reactome.org link: R-HSA-1855182