Reaction: I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,4,5,6-tetrakisphosphate (I(1,4,5,6)P4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) (Nalaskowski et al. 2002, Chang & Majerus 2006).
Reaction - small molecule participants:
ADP [nucleoplasm]
I(1,3,4,5,6)P5 [nucleoplasm]
ATP [nucleoplasm]
I(1,4,5,6)P4 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855185
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Reaction input - small molecules:
ATP(4-)
1D-myo-inositol 1,4,5,6-tetrakisphosphate
Reaction output - small molecules:
ADP(3-)
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reactome.org link: R-HSA-1855185