Reaction: 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 1-diphospho-3,4,5,6-tetrakisphosphate (1-PP-IP4) to form inositol 1,5-bisdiphospho-3,4,6-trisphosphate (1,5-(PP)2-IP3) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [cytosol]
1,5-(PP)2-IP3 [cytosol]
ATP [cytosol]
1-PP-IP4 [cytosol]
Reactome.org reaction link: R-HSA-1855193
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Reaction input - small molecules:
ATP(4-)
1-diphospho-1D-myo-inositol 3,4,5,6-tetrakisphosphate
Reaction output - small molecules:
ADP(3-)
1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate
Reactome.org link: R-HSA-1855193