Reaction: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).
The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008).
The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
5-PP-IP5 [nucleoplasm]
ATP [nucleoplasm]
IP6 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855207
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Reaction input - small molecules:
ATP(4-)
myo-inositol hexakisphosphate(12-)
Reaction output - small molecules:
ADP(3-)
5-diphospho-1D-myo-inositol pentakisphosphate(13-)
Reactome.org link: R-HSA-1855207