Reaction: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
5-PP-IP5 [nucleoplasm]
ATP [nucleoplasm]
IP6 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855207

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Reaction input - small molecules:
ATP(4-)
ChEBI:30616
myo-inositol hexakisphosphate(12-)
ChEBI:58130
Reaction output - small molecules:
ADP(3-)
ChEBI:456216
5-diphospho-1D-myo-inositol pentakisphosphate(13-)
ChEBI:58628
Reactome.org link: R-HSA-1855207