Reaction: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
- in pathway: Synthesis of IP3 and IP4 in the cytosol
Type II inositol-1,4,5-trisphosphate 5-phosphatase (INPP5B) is attached to the plasma membrane where it dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3 (Jefferson & Majerus 1995, Ross et al. 1991, Schmid et al. 2004). INPP5B is isoprenylated at its C-terminus for membrane attachment.
Reaction - small molecule participants:
Pi [cytosol]
I(1,3,4)P3 [cytosol]
H2O [cytosol]
I(1,3,4,5)P4 [cytosol]
Reactome.org reaction link: R-HSA-1855213
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Reaction input - small molecules:
water
1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
Reaction output - small molecules:
hydrogenphosphate
1D-myo-inositol 1,3,4-trisphosphate(6-)
Reactome.org link: R-HSA-1855213