Reaction: IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1/2 (PPIP5K1) and 2 (PPIP5K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5)) (Fridy et al. 2007, Mulugu et al. 2007, Choi et al. 2007, Lin et al. 2009; Wang et al. 2011).
Reaction - small molecule participants:
ADP [cytosol]
1-PP-IP5 [cytosol]
ATP [cytosol]
IP6 [cytosol]
Reactome.org reaction link: R-HSA-1855216
======
Reaction input - small molecules:
ATP(4-)
myo-inositol hexakisphosphate(12-)
Reaction output - small molecules:
ADP(3-)
1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate(13-)
Reactome.org link: R-HSA-1855216