Reaction: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
- in pathway: Synthesis of pyrophosphates in the cytosol
Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) phosphorylate inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) to inositol 5-diphospho-(1,3,4,6)-tetrakisphosphate (5-PP-IP4) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [cytosol]
5-PP-IP4 [cytosol]
ATP [cytosol]
I(1,3,4,5,6)P5 [cytosol]
Reactome.org reaction link: R-HSA-1855223
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Reaction input - small molecules:
ATP(4-)
myo-inositol 1,3,4,5,6-pentakisphosphate(10-)
Reaction output - small molecules:
ADP(3-)
5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate
Reactome.org link: R-HSA-1855223