Reaction: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5) to inositol 5-triphospho- 1,2,3,4,6-pentakisphosphate (5-PPP-IP5) (Saiardi et al. 2001, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Draskovic et al. 2008). While this reaction has been demonstrated to occur in vitro, the extent to which it occurs in vivo is less clear.
Reaction - small molecule participants:
ADP [nucleoplasm]
5-PPP-IP5 [nucleoplasm]
ATP [nucleoplasm]
5-PP-IP5 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855224
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Reaction input - small molecules:
ATP(4-)
5-diphospho-1D-myo-inositol pentakisphosphate(13-)
Reaction output - small molecules:
ADP(3-)
5-triphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
Reactome.org link: R-HSA-1855224