Reaction: IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
- in pathway: Synthesis of IPs in the ER lumen
In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1,2,4,5,6-pentakisphosphate (I(1,2,4,5,6)P5) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).
Reaction - small molecule participants:
Pi [endoplasmic reticulum lumen]
I(1,2,4,5,6)P5 [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
IP6 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-1855225
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Reaction input - small molecules:
water
myo-inositol hexakisphosphate(12-)
Reaction output - small molecules:
hydrogenphosphate
1D-myo-inositol 1,2,4,5,6-pentakisphosphate
Reactome.org link: R-HSA-1855225