Reaction: 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus
- in pathway: Synthesis of IPs in the nucleus
In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate5-diphospho-1,3,4,6-tetrakisphosphate (5-PP-IP4) to inositol 1,5-bisdiphospho-3,4,6-trisphosphate (1,5-(PP)2-IP3) (Saiardi et al. 2001, Saiardi et al. 2000, Draskovic et al. 2008).
Reaction - small molecule participants:
ADP [nucleoplasm]
1,5-(PP)2-IP3 [nucleoplasm]
ATP [nucleoplasm]
5-PP-IP4 [nucleoplasm]
Reactome.org reaction link: R-HSA-1855230
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Reaction input - small molecules:
ATP(4-)
5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate
Reaction output - small molecules:
ADP(3-)
1,5-bis(diphospho)-1D-myo-inositol 3,4,6-trisphosphate
Reactome.org link: R-HSA-1855230