Reaction: GBA2 hydrolyzes GlcCer (plasma membrane)
- in pathway: Glycosphingolipid catabolism
Human glucosylceramidase 2 (GBA2) hydrolyzes the glucosidic bond of glucocerebrosides (GlcCer) to form ceramide at the plasma membrane (Matern et al. 2001, Boot et al. 2007).
Reaction - small molecule participants:
CERA [plasma membrane]
Glc [cytosol]
H2O [cytosol]
GlcCer [plasma membrane]
Reactome.org reaction link: R-HSA-1861788
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Reaction input - small molecules:
water
GlcCer
Reaction output - small molecules:
N-acylsphingoid
alpha-D-glucose
Reactome.org link: R-HSA-1861788