Reaction: GBA3 hydrolyzes GlcCer (cytosol)
- in pathway: Glycosphingolipid catabolism
Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). However, the activity of GBA3 is relatively low and its significance in vivo is not clear (Dekker et al., 2011).
Reaction - small molecule participants:
CERA [cytosol]
Glc [cytosol]
H2O [cytosol]
GlcCer [cytosol]
Reactome.org reaction link: R-HSA-1861789
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Reaction input - small molecules:
water
GlcCer
Reaction output - small molecules:
N-acylsphingoid
alpha-D-glucose
Reactome.org link: R-HSA-1861789