Reaction: Ade-Rib binds AODORA2A and NTRK1,2
- in pathway: NGF-independant TRKA activation
Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, Ade-Rib binds ADORA2A and NTRK1 and NTRK2.
Reaction - small molecule participants:
Ade-Rib [cytosol]
Reactome.org reaction link: R-HSA-187661
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Reaction input - small molecules:
adenosine
Reaction output - small molecules:
Reactome.org link: R-HSA-187661