Reaction: XYLTs transfer Xyl to core protein
Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step in the tetrasaccharide linkage required for glycosaminoglycan biosynthesis. This reaction can take place in the Golgi apparatus and endoplasmic reticulum (not shown here). XYLTs mediates the transfer of xylose from the active nucleotide sugar UDP-xylose to specific serine hydroxy groups in the core protein. A C-terminal DxD motif on the enzyme is thought to be critical for activity (Muller et al. 2005, Goetting et al. 2004, Voglmeir et al. 2007).
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-Xyl [Golgi lumen]
Reactome.org reaction link: R-HSA-1878002
======
Reaction input - small molecules:
UDP-alpha-D-xylose(2-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-1878002