Reaction: Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)
- in pathway: Triglyceride catabolism
FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.
Reaction - small molecule participants:
FADH2 [mitochondrial matrix]
DHAP [mitochondrial matrix]
FAD [mitochondrial matrix]
G3P [mitochondrial matrix]
FADH2 [mitochondrial matrix]
DHAP [mitochondrial matrix]
FAD [mitochondrial matrix]
G3P [mitochondrial matrix]
Reactome.org reaction link: R-HSA-188467
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Reaction input - small molecules:
FAD(3-)
sn-glycerol 3-phosphate(2-)
FAD(3-)
sn-glycerol 3-phosphate(2-)
Reaction output - small molecules:
FADH2(2-)
glycerone phosphate(2-)
FADH2(2-)
glycerone phosphate(2-)
Reactome.org link: R-HSA-188467