Reaction: B3GAT dimers transfer GlcA to tetrasaccharide linker
B3GAT1 (Kitagawa et al. 1998) and B3GAT2 (Marcos et al. 2002) transfer a glucuronate (GlcA) residue via a beta1,3-linkage to a terminal galactose. The B3GATs are homodimeric and require manganese as a cofactor (Kakuda et al. 2004, Ouzzine et al. 2000). The tetrasaccharide linker is now complete, ready to accept further hexosamine additions. The type of hexosamine added is critical in determining which glycosaminoglycan (GAG) is formed.
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-GlcA [Golgi lumen]
Reactome.org reaction link: R-HSA-1889955
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Reaction input - small molecules:
UDP-alpha-D-glucuronate(3-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-1889955