Reaction: BIL translocates from the cytosol to the ER lumen
- in pathway: Heme degradation
The enzyme which catalyzes the conjugation of bilirubin (UGT1A1) is found in the ER. Bilirubin translocates to the ER, probably by simple diffusion, to be glucuronylated (Schröter 1972). To date, no transporter has been identified for this process (Fujiwara & Itoh 2014).
Reaction - small molecule participants:
BIL [endoplasmic reticulum lumen]
BIL [cytosol]
Reactome.org reaction link: R-HSA-189381
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Reaction input - small molecules:
bilirubin(2-)
Reaction output - small molecules:
bilirubin(2-)
Reactome.org link: R-HSA-189381