Reaction: FGFR2c binds to FGF
- in pathway: FGFR2c ligand binding and activation
In this reaction, FGF receptor 2c in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2c generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.
Reaction - small molecule participants:
HS [extracellular region]
Reactome.org reaction link: R-HSA-190258
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Reaction input - small molecules:
heparan sulfate
Reaction output - small molecules:
Reactome.org link: R-HSA-190258