Reaction: FGFR4 binds to FGF
- in pathway: FGFR4 ligand binding and activation
In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Also, TGFBR3 (beta-glycan) facilitates the binding of FGF2 with its receptor FGFR1 by binding with FGF2 itself and bringing more ligands into receptor proximity (Andres et al. 1992, Knelson et al. 2013).
Reaction - small molecule participants:
HS [extracellular region]
Reactome.org reaction link: R-HSA-190265
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Reaction input - small molecules:
heparan sulfate
Reaction output - small molecules:
Reactome.org link: R-HSA-190265