Reaction: Autocatalytic phosphorylation of FGFR4
- in pathway: FGFR4 ligand binding and activation
The intrinsic protein tyrosine kinase activity of activated FGF receptor 4 catalyzes multiple phosphorylation events, creating a number of binding sites for membrane bound docking proteins to gather intracellular signaling mediators. Based on sequence alignment, FGFR4 contains 5 of the 8 cytoplasmic tyrosine residues identified in FGFR1.
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-190326
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-190326