Reaction: NICD1 is phosphorylated by CDK8
- in pathway: NOTCH1 Intracellular Domain Regulates Transcription
CDK8 phosphorylates conserved serine residues in the TAD and PEST domains of NICD1. Phosphorylation targets NICD1 for ubiquitination and degradation, ultimately terminating transcriptional activity of NOTCH1 (Fryer et al. 2004).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-1912391
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-1912391