Reaction: MVD decarboxylates MVA5PP to IPPP
- in pathway: Synthesis of Dolichyl-phosphate
Mevalonate pyrophosphate decarboxylase (MPD) decarboxylates mevalonate-5-pyrophosphate (MVA5PP) into isopentenyl pyrophosphate (IPPP) while hydrolysing ATP to ADP and orthophosphate (Toth & Huwyler 1996).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
CO2 [cytosol]
IPPP [cytosol]
ATP [cytosol]
MVA5PP [cytosol]
Pi [cytosol]
ADP [cytosol]
CO2 [cytosol]
IPPP [cytosol]
ATP [cytosol]
MVA5PP [cytosol]
Reactome.org reaction link: R-HSA-191414
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Reaction input - small molecules:
ATP(4-)
(R)-5-diphosphomevalonic acid
ATP(4-)
(R)-5-diphosphomevalonic acid
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
carbon dioxide
isopentenyl diphosphate
hydrogenphosphate
ADP(3-)
carbon dioxide
isopentenyl diphosphate
Reactome.org link: R-HSA-191414