Reaction: 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
5beta-cholestan-3alpha, 7alpha, 12alpha, 27-tetrol and NADP+ react to form 3alpha, 7alpha, 12alpha-trihydroxy-5beta-cholestan-27-al and NADPH + H+. This oxidation reaction occurs in the mitochondrial matrix, catalyzed by CYP27A1.
Reaction - small molecule participants:
H+ [mitochondrial matrix]
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al [mitochondrial matrix]
NADPH [mitochondrial matrix]
5bCHOL3a,7a,12a,27-tetrol [mitochondrial matrix]
NADP+ [mitochondrial matrix]
Reactome.org reaction link: R-HSA-192042
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Reaction input - small molecules:
5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
NADP(+)
Reaction output - small molecules:
hydron
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al
NADPH
Reactome.org link: R-HSA-192042