Reaction: CYP27A1 27-hydroxylates CHOL
- in pathway: Endogenous sterols
Cholesterol CHOL), NADPH + H+, and O2 react to form 27-hydroxycholesterol (27OH-CHOL), H2O, and NADP+, in the mitochondrial matrix, catalysed by CYP27A1. 27OH-CHOL is the most abundant oxysterol in human plasma. Its formation is thought to play a central role in the mobilization of CHOL from non-hepatic tissues (Cali et al. 1991).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
27OH-CHOL [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CHOL [mitochondrial matrix]
NADPH [mitochondrial matrix]
NADP+ [mitochondrial matrix]
27OH-CHOL [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
CHOL [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-192123
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Reaction input - small molecules:
dioxygen
hydron
cholesterol
NADPH
dioxygen
hydron
cholesterol
NADPH
Reaction output - small molecules:
NADP(+)
26-hydroxycholesterol
water
NADP(+)
26-hydroxycholesterol
water
Reactome.org link: R-HSA-192123